Pathways to Success Seminar: Learn About the Immune Monitoring Core
On Thursday, January 26, 2023, at noon, learn how Einstein’s Immune Monitoring Core can aid your research during the bimonthly Pathways to Success at Einstein Cores seminar series, accessible via Zoom. To begin, Yvonne Saenger, M.D., core scientific director, and Lawrence Leung Ph.D., operations director, will provide an overview of the resources and services of the core, then Nora Prior, Ph.D., and Kosaku Shinoda, Ph.D., will share how the core has enhanced their respective research efforts.
An example of data visualization provided by the immune monitoring core
About the Immune Monitoring Core
The Immune Monitoring Core provides complete sample-to-data service for clinical and translational investigators who need access to technologies such as multiplex immunofluorescent imaging and spatial transcriptomics. Core staff minimize the hands-on work so investigators can spend more time analyzing their data and testing their hypotheses.
The core specializes in imaging the tumor microenvironment, assisting investigators in validating phenotypic signatures of immune and tumor cells.
Core Services
The Immune Monitoring Core facility has full- time, dedicated staff who operate the following equipment for investigators:
- Leica Bond-RX Mulitplex IHC Stainer
- Akoya PhenoImager HT whole slide scanner
- nanoString nCounter Pro Analysis System
- nanoString GeoMX Digital Spatial Profiler
For details describing each piece of equipment and how it can be used, view the core’s page.
It’s Been Said:
“The Immune Monitoring core provides complete sample-to-data service for clinical and translational investigators who need access to technologies such as multiplex immunfluorescent imaging and spatial transcriptomics. We specialize in imaging the tumor microenvironment, assisting investigators in validating phenotypic signatures of immune and tumor cells.”
Lawrence Leung, Ph.D.
Operations Director
“The core offers immune phenotyping of clinical grade FFPE samples using quantitative multiplexed immunofluorescence (Phenocycler) and NanoString assays.?Phenocycler allows for identification and spatial localization of immune cells using up to nine markers on the same tissue while NanoString quantitates up to 800 gene transcripts per sample. These methods work on FFPE, require minimal tissue, and are high throughput.”
Yvonne Saenger, M.D.
Immunotherapy Director
“I reached out to four different genomics cores before deciding to work with Larry and the researchers at the Einstein Immune Monitoring Core. They immediately impressed me by how quickly they responded, how patiently they answered my questions, and how curious and engaged they were in our research. I am recommending this core to my colleagues now!”
Nora Prior, Ph.D.
Senior Research Associate, Cornell University
“The Immune Monitoring Core was very flexible in accommodating my urgent request before a grant deadline, and Larry was able to quickly perform gene expression analysis of clinical skin biopsies. I have been using RNA- sequencing for almost 15 years now, and the technology of this core should replace a large portion, if not all, of the gene expression currently done by RNA-sequencing in terms of speed and flexibility. I highly recommend clinicians and scientists at Einstein using the Immune Monitoring Core for such investigative needs.”
Kosaku Shinoda, Ph.D.
Assistant Professor, Medicine; Molecular Pharmacology, Einstein
Posted on: Tuesday, January 17, 2023